Glutamate is the most abundant amino acid in the diet, but is usually bound up in proteins. In its free form, it contributes to the umami taste, which is the savory flavor associated with meat and mushrooms. Long, slow cooking and fermenting can both bring out this flavor.⠀
Unfortunately, some people don’t tolerate glutamate well. Glutamate sensitivity is controversial, but some of the symptoms people say they experience are headaches, sweating, flushing, or sets of symptoms that mimic allergies. If you don’t tolerate slowly cooked protein foods or fermented foods, you may have glutamate sensitivity. If you do, an oxaloacetate supplement may help.
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If you know you’re sensitive to glutamate, or if you may be sensitive to glutamate because you know that you react negatively to protein-based foods that have been cooked for long periods of time, such as bone broth, or to fermented foods, then this video is for you.
Hi. I’m Dr. Chris Masterjohn of chrismasterjohnphd.com. And you’re watching Chris Masterjohn Lite, where the name of the game is “Details? Shmetails. Just tell me what works!”
Katherine Morrison says on Facebook: I was hoping Chris Masterjohn could explain why glutamat is a problem for some of us 😉 Katherine, I’ve never been able to wink my entire life, but I’ll say back at you winky wink.
Now glutamate is ordinarily cleared in a vitamin B6-dependent manner by a compound known as oxaloacetate. Oxaloacetate is a compound that’s main use is to help us burn fuel for energy. However, on an as-needed basis, we’ll use oxaloacetate to get rid of extra glutamate in our system.
If you’re deficient in vitamin B6, this itself could cause the problem, and would actually limit your ability to respond to what I’m suggesting in this video, which is oxaloacetate supplementation. Ordinarily we derive oxaloacetate from carbohydrate. If we’re eating a low-carbohydrate diet, we’ll get it from protein. If we’re eating a diet that’s low in carbohydrate and protein, then that could be the problem right there.
But, assuming that’s not the case, there is a long list of genetic, metabolic, nutritional, toxic etc. problems that could interfere with our ability to clear glutamate. The list is so long that it would be really difficult to go one by one and do the detective work to figure out with what may be the problem.
So, I would suggest starting by trying an oxaloacetate supplement. The reason that this is good, also, is because if you know you respond well to the oxaloacetate supplement, then suddenly that limits the potential explanations to anything that could be interfering with your ability to make enough oxaloacetate. Given that, it’s a great starting place. There’s two oxaloacetate supplements that I know of. One is called BenaGene, and you can get it at benagene.com. That’s B E N A G E N E dot com.
The other is Ketoprime. You can get it at bulletproof.com/ketoprime. K E T O P R I M E. Both of these come in 100 mg per capsule. We know from a relatively modern study, that in Alzheimer’s patients, a hundred milligrams twice a day is safe and effectively absorbed. We also know from a really old study that oxaloacetate appears to be safely tolerated in up to a thousand milligrams per day in diabetics.
In fact that really old study suggested that oxaloacetate may even help treat diabetes. Without going into that now, I would say if you have a glutamate problem, or you suspect a glutamate problem, it would be great to try anywhere between 200 mg per day and a 1,000 mg per day, divided in three doses, to see if it helps.
Now, I know anecdotally, some people get digestive stress if they take more than 200 mg at a time, so keep that in mind. Work up slowly. And if you have a serious problem with glutamate, that goes beyond what you can safely tolerate experimenting with, then don’t experiment with it.
Only try this if you can judge from your own experience, that whatever your reaction to glutamate is, it’s safe and it’s tolerable enough to be worth doing a little experiment like this one. There aren’t any studies documenting that oxaloacetate supplementation will help with glutamate sensitivity. Nevertheless it makes sense. And so I think that if you wanna try this, I would love to hear how it works. Or if it doesn’t work.
All right, I hope you found this useful. Signing off, this is Chris Masterjohn of chrismasterjohnphd.com. You’ve been watching Chris Masterjohn Lite, and I will see you in the next video.