Question: Does mixing carbohydrate with fat cause people to get fat because of the Randle cycle There’s a theory floating around on the internet that mixed diets are more fattening than low-carb or low-fat diets because of the metabolic competition between glucose and fatty acids. I don’t believe this to be true because, in the …
Question: What to do if gamma-tocopherol levels are low-normal while taking 100 IU/d of alpha-tocopherol. My initial impression is that there is nothing wrong because I don’t care that much about gamma tocopherol. My doctoral research specialized in gamma tocopherol and there is some evidence that gamma tocopherol does some things that alpha tocopherol doesn’t …
Question: What to do if taking biotin and yet beta-hydroxyisovalerate is elevated. Well in theory that’s a marker of biotin deficiency, but you might have a defect in a biotin-dependent enzyme so you can try 5 milligrams, but if you still have high beta hydroxy isovaleric you need to start looking at a metabolic disorder, …
Question: For someone who is taking 45 mg of vitamin B6 as P5P but has xanthurenate, kynurenate, and quinolinate high in the urine as markers of vitamin B6 deficiency, and who is a man with high estrogen, what should they do? If you have xanthurenate and kynurenate spilling into your urine, it means that quinolinate …
Question: For someone who is homozygous for the H63D allele of the iron- and hemochromatosis-related HFE gene, if ferritin is low but transferrin saturation is high, should they still donate blood? H63D is one of the genes that predisposes to hemochromatosis, a condition of iron overload. Most clinicians who work in this area do not …
Question: Thoughts on lowering my resting heart rate. It’s often in the high 80s or low 90s once I’m up for the day. I wish I knew the answer to that. I’d use it for my heart rate. I don’t even measure my heart rate because my whole life it’s been kind of high. I …
Question: How to manage the zinc-to-copper ratio and what to do if zinc and copper are both low-normal when supplementing with 15 mg of zinc and 1 mg of copper. I don’t recommend looking at the zinc-to-copper ratio. Although there are studies correlating health endpoints with the zinc-to-copper ratio, I do not believe that it …
Question: What nutrients are needed to break down old, damaged bone and build new, healthy bone? So you are breaking down bone all the time throughout every second of your life. We are always breaking down bone, we are always building up new bone, and if you had any kind of defect in the ability …
Question: What are my thoughts on detoxing heavy metals? My thoughts are first you need to look at how bad the heavy metal is and if it is even at a level that a conventional practitioner would say you have toxicity; for example lead. If this is your situation then I don’t feel comfortable advising …
Question: What to do about elevated morning blood glucose in the mid 90s. I think usually your morning glucose is primarily impacted by your hormones and very rarely impacted by what you ate the night before, unless you are severely glucose intolerant. So the overwhelming probability is that if your blood glucose is elevated in …