Question: Milk thistle, sulforaphane, and blood donation for iron overload If it’s an uptrend, you probably want to do something about it. Someone in that situation could try the Nrf2 stimulators, like milk thistle and sulforaphane. But if it is a genuine uptrend in early stage iron overload, that might be a situation that giving …

Question: Why would methylated vitamins increase pain sensitization? I’m not sure. Just to throw out some random threads that may or may not be of use. I think methylation in some people is going to lead to increased synthesis of dopamine. But in general, the effect is going to be to decrease the tonic pool …

Question: Why would ferritin and B12 increase on a low-calorie keto diet? Ferritin is very strongly influenced by inflammation, oxidative stress. And so if the iron status is not changing and the ferritin is going up and then down, to me that suggests that oxidative stress or inflammation is increasing in the hypocaloric state. I …

Question: Why are polyunsaturated fats more easily burned for energy than saturated fats? I don’t know in detail the mechanism, but I do know that it’s been shown in human cells and in live animal experiments. And it presumably is related to the affinity of the enzyme for the fatty acid. And that’s not something …

Question: Why zinc deficiency causes resistance to thyroid and sex hormones and vitamins A and D The answer to that is because the, because all of those things carry out their gene expression function by binding to nuclear receptors. And all of the nuclear receptors to DNA using zinc finger motifs. Zinc finger motif means …

Question: Which nutrients do we need every single day? I would say that the top ones to be concerned about from a have-to-get-it-today perspective would be zinc and B12. And both of those have absorption caps that are fairly tight, but B12 is the number one concern. You want to pay decent attention to the …