Question: What’s a better nasal spray, Sterimar or povidone-iodine? It’s hard to say. So the Povidone-iodine obviously has some contraindications and it has contraindications mostly because it’s been so commonly used in a medical setting and therefore has so much known about its safety and risk profile and I don’t have any particular reason to …
Do postmenopausal women need to worry about iron overload? | Masterjohn Q&A Files #150
Question: Do postmenopausal women need to worry about iron overload? Generally, it’s not men who are necessarily predisposed to iron buildup. It’s men with some genetic predisposition to that, so maybe less than 10% of men. But yeah, postmenopausal women with the same genetics will, like men, be vulnerable to that. When you stop menstruating, …
Should NAC supplementation be pulsed? | Masterjohn Q&A Files #149
Question: Should NAC supplementation be pulsed? So, yes, boost glutathione. It might bring glutathione down. It’s speculative that you could pulse it to avoid that. But even supplementing oral glutathione for 6 months was shown to not affect glutathione production. And certainly, oral glutathione is going to have more of a negative feedback loop than …
Why would my threonine levels be low? | Masterjohn Q&A Files #148
Question: Why would my threonine levels be low? The two things I can think of are increased gluconeogenesis and increased conversion of methylglyoxal, both of which I would expect to be driven by a low carbohydrate diet. Then of course, it could also be not enough protein consumption. But if it’s why threonine is being …
What’s the best alcohol to microdose? | Masterjohn Q&A Files #147
Question: What’s the best alcohol to microdose I prefer red wine on a taste, and tradition, and aesthetic basis. Just for background, I think Half a drink to a drink a day is probably the net maximal benefit for alcohol and that can be averaged. It doesn’t have to be every day. And that’s the …
What’s the best nutrition for panic and anxiety? | Masterjohn Q&A Files #146
Question: What’s the best nutrition for panic and anxiety? Methylation is overwhelmingly important. I do think that other factors impacting dopamine can be relevant in the sense that the main way that methylation regulates mental rigidity is through decreasing the pool of tonic dopamine, which favors mental flexibility. And so, you can also favor mental …