Short Answer: I believe most methyl donor intolerances are a result of deficiencies in the glycine buffer system, which requires glycine, vitamin A, fasting (glucagon), androgens, riboflavin, unmethylated folate (THF), and iron. No one should expect to tolerate 30 milligrams of folate, however, and there is almost never a reason to use doses that high.

Question: Does whey protein hurt the kidneys or otherwise hurt our health? Short Answer: The main problem with too much protein, particularly animal protein, is that acidity may hurt the bones and increase the risk of calcium oxalate kidney stones, but this can be obviated by balancing it with organic acids, which have bicarbonate-sparing effects that are …

Does glucose handling in the brain decline with age? And if so, does this serve as a rationale to supplement with MCT oil to prevent cognitive decline? Short Answer: Energy metabolism in general declines across the body with aging, but energy metabolism seems to stay healthy enough in the brain in people who do not …

Short Answer: If it can’t be explained by the dose of salt, it may be that the salt is not being absorbed orally. Glucose, starch, or simply a meal consumed alongside the salted water may help with this.

Short Answer: SHBG is increased by adiponectin (vitamin K2, insulin sensitivity), thyroid hormone, fasting physiology (AMPK, fat oxidation), and estrogen (especially estrone), while it is decreased by insulin resistance, obesity, the fed state and carbohydrate-dominant physiology, androgens, and polyunsaturated fat. This episode was cut from the original Q&A session that you can find here. DISCLAIMER: I have …

Short Answer: While protein restriction may have value in people with established cancer or kidney disease, cycling robustly between fasting and feeding states is likely to provide all the value that restriction of protein or calories might otherwise provide, and a high protein intake supports bone mass, muscle mass, and the detoxification of carcinogens, all …