On Tuesday, I wrote to you about new study showing that SARS-CoV-2, the coronavirus that causes COVID-19, infects the throat, not just the lungs, and the infection may actually start in the throat before it starts in the lungs. And since the evidence for infecting the throat came from either oropharyngeal swabs (swabs of the …
Are there safety concerns in supplementing in those with MTHFR polymorphisms? | Masterjohn Q&A Files #97
Question: Are there safety concerns in supplementing cyanocobalamin rather methylcobalamin in those with MTHFR polymorphisms? If you’re concerned about methylation-related issues, you would want to be careful with methylcobalamin supplementation in a way that you would not need to be careful about hydroxocobalamin supplementation. If you don’t have a specific methylation-related goal, then I think …
If You Are Sick, What Are the Chances It’s the Coronavirus? [COVID-19 Updates]
If you feel sick, what are the chances it’s the coronavirus? Researchers from the Los Angeles Departments of Public Health and Health Services and the Los Angeles County and University of Southern California Medical Center tested everyone who presented with mild flu-like illness to the emergency room or urgent care on March 12, 13, 15, …
ACE2 Explains Why Smoking Leads to Worse COVID-19 Outcomes [COVID-19 Updates]
A new study (as with virtually all circulating information on COVID-19, not yet peer-reviewed), shows that ACE2 can easily explain why smoking is correlated with worse outcomes in COVID-19. Background ACE2 is an enzyme whose normal role in our physiology is to lower our blood pressure, and to prevent damage to tissues from fibrosis (laying …
What about pyroluria and measuring kryptopyrroles? | Masterjohn Q&A Files #96
Question: What about pyroluria and measuring kryptopyrroles? I think it’s fairly harmless to increase zinc and B6 as a test of whether that’s true and see if you get results from it. But I wouldn’t treat it like a diagnostic value because no one has followed up any science on that disorder in the decades …
How to manage blood levels of omega-3 and omega-6 fatty acids. | Masterjohn Q&A Files #95
Question: How to manage blood levels of omega-3 and omega-6 fatty acids. I don’t specifically want to look at the omega-3-to-omega-6 ratio. The AA/EPA ratio, I do not believe in wanting to get it low enough to prevent inflammation. I don’t believe in using it that way. But I do believe that if it were …