Does it matter what form of B12 you take? | Masterjohn Q&A Files #91

Question:  Does it matter what form of B12 you take? Cyanocobalamin is cheap and there’s not really any clear evidence that it’s harmful, but I just don’t like the idea that it is cobalamin bound to cyanide. It’s not found in the food supply. Forming cyanocobalamin and peeing it out is actually one of the …

Why AGEs and deficient insulin signaling are the main problem in diabetes. | Masterjohn Q&A Files #89

Question: Why AGEs and deficient insulin signaling are the main problem in diabetes. The reason that methylglyoxal, which I did my doctoral dissertation on, the reason that methylglyoxal, which is quantitatively the most important form of advanced glycation end products in diabetics, the reason that it is elevated is not because of hyperglycemia. It’s because …

Nutritional recommendations for MTR and MTRR polymorphisms. | Masterjohn Q&A Files #88

  Question: Nutritional recommendations for MTR and MTRR polymorphisms In the methylation cycle, I’ve talked a lot about MTHFR, which helps finalize the methyl group of methyfolate. But then folate has to donate that methyl group to vitamin B12 in order for vitamin B12 to donate it to homocysteine. In that process, that’s how you …

Nutrients important for neuroregeneration. | Masterjohn Q&A Files #86

Question: Nutrients important for neuroregeneration. Iron, phosphorus, and sulfate are very important for regenerating nerves. Magnesium. Acetylcholine is a major factor in regeneration of nerves, and so choline is important. If you were to use a supplement, alpha-GPC would be the ideal choline supplement to use because it’s superior at generating acetylcholine. Vitamin A and …