Where Do Most AGEs Come From? O Glycation, How Thy Name Hast Deceived Me!

I’ve written a few posts about advanced glycation endproducts (AGEs) in the past, which can be found here.  These posts include a refutation of the common belief that the “receptor for AGEs” (RAGE) is actually a receptor for AGEs, and a refutation of the implausible and unreliable data suggesting that butter is a major source …

Genes, LDL-Cholesterol Levels, and the Central Role of LDL Receptor Activity In Heart Disease

Are high concentrations of LDL-cholesterol a major cause of heart disease?  If we are a proponent of the “lipid hypothesis,” we say yes.  If we are a “cholesterol skeptic,” we say no — total cholesterol, LDL-cholesterol, LDL particles, triglycerides, and other blood lipids have little or nothing to do with heart disease. I believe both of these positions …

Eating Fat and Diabetes — Response to Bix Weber

Melissa McEwen recently brought to my attention a blog post by Bix Weber, the Fanatic Cook, “Diabetes is a Disorder of Fat Metabolism.” Weber cites a 2009 study published in The Journal of Clinical Investigation entitled “Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans” …

What Can Modern Toxicology Tell Us About Food Toxins and Food Intolerances?

“The dose makes the poison.” — Paracelsus (1493-1541) “What is food to one is bitter poison to others.” — Lucretius (ca. 99 BC — ca. 55 BC) This post will be the first in a series of posts on food toxins and food intolerances.  As an introduction, I’d like to review some of the recent …

Meeting the Choline Requirement — Eggs, Organs, and the Wheat Paradox

In several recent posts, I argued that most of us aren’t getting enough choline, and that the disappearance of choline-rich foods like liver and egg yolks from the modern diet is likely responsible for the silent epidemic of fatty liver disease that may be afflicting 70-100 million Americans.  If you missed them, you can find them …