The MTHFR and Methylation Checklist

Here’s your seven-step checklist to make sure you’re on top of your methylation needs: 1. Have your genetics analyzed using 23andMe, Ancestry, or Self-Decode. 2. Download the raw data file and run it through my free choline calculator. 3. Use the calculator’s estimate of your choline requirement to determine your personal need for how much …

Is dairy safe for overmethylators? | Masterjohn Q&A Files #217

Question: Is dairy safe for overmethylators? There’s so little methylcobalamin in milk that I think that it is totally insignificant with regards to methyl groups, coming into the methylation cycle. Generally, if you’re experiencing over-methylation symptoms from methylcobalamin or methylfolate, I think the big issue is partly that you don’t have enough glycine in the …

Why would methylated vitamins increase pain sensitization? | Masterjohn Q&A Files #196

Question: Why would methylated vitamins increase pain sensitization? I’m not sure. Just to throw out some random threads that may or may not be of use. I think methylation in some people is going to lead to increased synthesis of dopamine. But in general, the effect is going to be to decrease the tonic pool …

What are the best ways to stabilize blood sugar? | Masterjohn Q&A Files #173

Question: What are the best ways to stabilize blood sugar? I would definitely be trying to lower the glucose response. And what I would do in such a situation would be to run a series of experiments on the type of carbohydrate, as well as the amount of carbohydrate, as well as the context of …

Do low serine levels require IV supplements? | Masterjohn Q&A Files #144

Question:  Do low serine levels require IV supplements? You’re probably just depleting serine through the CBS pathway and just eat more protein and consider supplementing glycine or collagen along with it. I don’t see why that would require IV supplements.  If you would like to be part of the next live Ask Me Anything About …