My New Wise Traditions Article, “Nutritional Adjuncts to the Fat-Soluble Vitamins,” Is Now Online!

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My new article from the Winter, 2012 issue of Wise Traditions, the quarterly journal of the Weston A. Price Foundation, is now up online! The article gives a brief history of how the concept of synergy between the fat-soluble vitamins repeatedly eluded us through the twentieth century, with a a little peak at the rise and fall of cod liver oil's popularity, and then dives into the roles of zinc, magnesium, fat, carbohydrate, carbon dioxide, and thyroid hormone in supporting the action of the fat-soluble vitamins. If you'd like to read it, you can find it here:

This article is based on my talk at the Wise Traditions 2012 conference by the same name. The upcoming spring journal will carry my article, “Meat, Bones, Organs, and Skin: Nutrition for Mental Health,” based off my other talk at the November conference, which covers the literature on vegetarianism and mental disorders, the roles of vitamin B12, folate, methionine, and glycine in supporting methylation, and the role of methylation in contributing to the regulation of dopamine, in turn regulating the balance of mental stability and mental fluidity that it is needed for optimal mental health.

If you like these articles and you'd like to offer financial support to the Weston A. Price Foundation, I highly suggest becoming a member, which entitles you among other things to a free subscription to the quarterly journal. It's much more pleasant to read these articles in print format than online, and you get to read them before they go online.If you'd like to become a member, you can do so for $40 ($25 for students, seniors, unemployed, and disabled) here.


Update December 17, 2016: If you enjoyed this, I encourage you to check out The Ultimate Vitamin K2 Resource. It has easy-to-read practical advice, click-to-expand technical explanations, infographics that explain the science in a fun way, supplement recommendations, and a searchable database of foods. This post as well as the resource are indexed with my other vitamin K-related writings at Start Here for Vitamin K2.

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  1. […] Summary: –Decrease and avoid all unnecessary: stress, toxins, allergens, and chronic inflammation to have a health metabolism. –See Mike’s post on low hanging fruit. –Visit and for fringe health ideas that actually work. Forget Paleo, Low-carb, veganism, and all other dietary dogma. Do what gets results in reality and allows you to thrive, long term. Danny’s Hair Like a Fox book logically pieces together why men go bald from a perspective no else mentions: a busted metabolism. Are you not interested? –Most people still think carbon dioxide is just a waste product. It isn’t. […]

  2. I definitely need to change my dose 🙂 it is funny how people are not aware of their daily habits and whether it is good or bad, accurate or not… they just listen to their aunt…. 🙂

    Thanks for the post !

  3. Yea, I actually was just talking to someone about fat-soluble vitamins, but they weren't hearing it. Thanks for sharing this post and backing up what I had been thinking!

  4. Interesting stuff Chris! Thanks for letting us know that your article is up and available in the online format. Now, am I correct in assuming that fat-soluble vitamins can be very beneficial for supporting good mental health?

  5. Brendan: Hyperventilation will do that =)It's why some (eg: Dr. Ray Peat) recommend breathing in a paper bag now and then.

  6. Hi Chris,

    About the relationship between thyroid and carbon dioxide:

    First of all, what do you think is an adequate concentration of CO2 in the blood?

    Secondly, what (to your knowledge) might cause CO2 concentrations to remain relatively low even when free T3 levels are quite high? Reverse T3? Free fatty acids?

    Thanks for your great work.

      1. Thorne K2 is 1 mg of K2 as MK-4. MK-4 has a half-life of only a few hours, and MK-4 is required in doses more like 15 mg three times a day. Chris, why aren’t you taking vitamin K2 as MK-7? It is detectable in the body for three days and is required in microgram doses. (Schurgers, et al. of Maastrickt University’s K2 research team has published over 30 studies on MK-7. Dr. Johan Hultin, the “Indiana Jones of Science” told me that he is taking 500 mcg. of MK-7 a day and scans show that his arterial plaque has receded. I’m curious that you selected MK-4. This post is over 3-years old. Perhaps you’ve changed since then. I am curious to hear your answer, though, as you are generally far ahead of the curve.

        1. Hi Michael,

          1) Half life is in the blood not “the body” and is totally irrelevant as vitamin K does not perform its functions in blood lipoproteins.

          2) There is no evidence that MK-4 is required in those doses.

          I have described benefits of MK-4. I am making an updated article soon that will expand the discussion.


          1. Further, Chris, according to PMID: 23140417

            Single dose administration of MK-4 (420 μg; 945 nmol) or MK-7 (420 μg; 647 nmol) was given in the morning together with standardized breakfast. MK-7 was well absorbed and reached maximal serum level at 6 h after intake and was detected up to 48 h after intake. MK-4 was not detectable in the serum of all subjects at any time point. Consecutive administration of MK-4 (60 μg; 135 nmol) or MK-7 (60 μg; 92 nmol) for 7 days demonstrated that MK-4 supplementation did not increase serum MK-4 levels. However, consecutive administration of MK-7 increased serum MK-7 levels significantly in all subjects.

          2. Hi Michael,

            Briefly, blood levels are not a relevant endpoint except for academic interest in pharmacokinetics, and studies using 45 mg are irrelevant to the question of the effects of lower doses.

            I’ll be coming out with a comprehensive resource on K2 in the next week or so.


    1. Chris, can you tell any difference, or measure any difference in any way, between when you're taking the K2 and when you're not? Just curious…

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