The Antioxidant System
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Introducing Masterclass with Masterjohn

Masterclass With Masterjohn 2: Energy Metabolism

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Masterclass With Masterjohn 1: The Antioxidant System

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  1. Hi. Tried relaying this message other ways with no success. I joined your vitamin masterclass 101. Something happened in the early stages and I didn’t get the vitamins before vit B3. Is there any way you can send to me? I tried resigning up and that didn’t work. Thank you so much, Marlene Lahman

  2. Chris,

    Thank you for this class, currently studying for my boards (Certified Nutrition Specialist) and these videos and info is super helpful. Looking forward to future classes!

  3. Hey Chris,

    Absolutely love all of your content. Quick question after having gone through the anti oxidant system videos.

    When the anti-oxidant defense system is upregulated due to oxidative stress, can this lead to decreased levels of micro nutrients like manganese,zinc, and selenium? When these are used to synthesize glutathione peroxidase and the SOD’s do they get used up for good, or can they be recycled in the way glutathione can? Of course context is very important, but I can see how making sure high level athletes, who are exposed to constant physical stress and ROS, would need to make sure levels of these micronutrients are adequate and probably have slightly above the ‘normal’ intake of them. I am hoping you can just let me know if this line of thinking is correct or if the system can somehow recycle these nutrients despite increased anti oxidant enzyme activity.

    Thanks for all your hard work.

    1. Hi Mike, they can be recycled, but they can’t be simultaneously used for other things. So, it doesn’t make them disappear, but it does raise your need for those nutrients. Also, there is always some rate of loss of any nutrient, and the more they are used, the more will be lost. So, it would probably cause some loss, but the larger effect would simply be that it is using nutrients for those purposes so that they cannot be used for other purposes.

  4. Thank you for these videos! I just finished the last one and they were excellent. The specific examples really helped elucidate complex topics that seemed much more abstract before I watched this, especially around lipid peroxidation. I thought the presentation of the information was logical and built upon itself well. I look forward to the next masterclass!

  5. Thanks Chris for these classes. Quick question: what role if any Testosterone has in anti-oxidant defence system?

    1. Raj, while everything is connected to everything else in some way, I don’t view testosterone as having a role in the antioxidant defense system.

  6. Thanks Chris! So thrilled to have these!!!! Just started watching, finished the first one and can’t wait to be able to continue. (Unfortunate time restraints).

  7. Hey Chris, great work.

    I’m thinking about supplementing with vitamin E. You mentioned that gamma is the most common tocopherol in the diet and that too much alpha can deplete it. If I were to supplement, should I take an equal amount of alpha and gamma, or should I take twice as much gamma?
    I found a page that reveals the amount of alpha and gamma in different oils and the only oils that contained more gamma than alpha were soybean and corn oil – which people weren’t consuming until recently. I was wondering what the ‘natural/paleo’ vitamin E ratio of alpha to gamma would be.
    Do you have any idea of the alpha and gamma ratio of grass-fed meats so I can make a decision for supplementing based on that knowledge? Thanks.

    1. Hi Anthony,

      I would limit it to 20 mg/d, and I would use something that is slightly biased towards alpha.


      1. Thanks! Yeah, I wish these supplement companies would sell stuff with lower doses. They all seem to contain 60-300mg.

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