Chris Masterjohn LITE talks about How to Know If Coffee Can Save Your Life
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If you're one of the 7% who have this gene, then drinking coffee may just save your life.

Rs73598374 is the RS number discussed in the video.

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1 Comment

  1. But this allele (which I have too) also increases mean lifespan (not maximum) because it decreases chances of heart disease. Nevertheless it is an Evil Allele because it makes people sleepy during the day, including poor memory, attention, and (in my opinion) general mood. I wonder if you could give your opinion on some supplements that I’ve read about (but not tried) to possibly help this Evil Allele have less hold on our lives.
    –DHEA (here’s a ref) : Method for reducing adenosine levels with a dehydroepiandrosterone and optionally a ubiquinone
    –theophylline
    –theobromine
    –inosine (which is decreased with this allele, but may compete with adenosine?)
    –zinc (if you’re deficient, it reduces adenosine deaminase)
    –luteolin (quote: because PDE converts cyclic AMP to AMP. AMP will then convert to adenosine. If you block the conversion with PDE inhibitors, you will have higher cyclic AMP and less AMP and adenosine
    –resveratrol, curcumin (inhibit various PDE enzymes)
    –theacrine (less tolerance than caffeine?)
    –creatine (see article: Creatine supplementation reduces sleep need and homeostatic sleep pressure in rats)
    –garlic (see article: Antihyperglycemic, antihyperlipidemic, anti-inflammatory and adenosine deaminase- lowering effects of garlic in patients with type 2 diabetes mellitus with obesity)

    Is there anything else you’ve found that works? Tired of being tired.
    Thanks!

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