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What to Do About Your COMT Genes

Do you have anxiety? Depression? Attention problems? Or are you worried about estrogen and cancer?

If so, watch this video to learn about the role of your COMT genetics.

COMT metabolizes dopamine, estrogen, and various other things. Half of us have the genetic for intermediate activity. The other half of us are split evenly between high and low activity. When nutrition is optimal, this just leads to personality differences: with low COMT activity, you’re better at focusing, but tend to ruminate on things rather than letting them go; with high COMT activity, you rarely get stuck in a rut, but you just as rarely sit down to focus on one single thing. When nutrition is off, we can go to pathological extremes, whether it’s depression and anxiety on one hand, or attention deficit and hyperactivity on the other. Robust COMT activity is also needed to get rid of harmful forms of estrogen that contribute to cancer risk.

I recommend testing your COMT genes with StrateGene, which you can get here:

chrismasterjohnphd.com/strategene

For more information on how to get the StrateGene report, watch this video, the first of the three MTHFR videos:

https://chrismasterjohnphd.com/2017/12/04/know-need-care-mthfr/

Here are the two other MTHFR videos:

https://chrismasterjohnphd.com/2017/12/06/what-to-do-about-mthfr/

https://chrismasterjohnphd.com/2017/12/11/bloodwork-get-mthfr/

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19 Comments

  1. Welp, thanks mother nature for sticking me with both rs4680 and rs4633 COMT met/met. I appreciate that there are some educated people out there attempting to answer questions about genetic phenotypes. It is incredibly difficult finding specialists and I have had to deal with ignorant medical professionals who are more opinionated than educated on genetic neurological and metabolic disorders. I also carry a rare genetic phenotype called Atypical BuChE. Fortunately, I am heterozygous. I had a doctor tell me not to worry and just wash the pesticides off of produce instead of purchase organic. He also didnt believe that people with Atypical BuChE have difficulty breaking down nightshade alkaloids. Again, this guy was far more interested in his opinion than actual data on a topic he knew little about *sigh*

  2. Hey Chris. Love your work and am incredibly grateful for the amount of information you put out. I’m curious if you’re accepting new patients.

    I learned that I’m compound heterozygous. Which has got me digging into the trenches. I know I need more methylation support, but b12 supplements along with methylfolate and folinic acid really knock me out and make me fatigued. Even at the lowest doses. I’m curious if you have any insight.

    I also have a question about betaine. I know you said you can use that to help with choline. Is 1 mg of choline equivalent to 1 mg of betaine? Also is betaine hcl equivalent to TMG

    1. I am not a health practitioner and do not treat patients. I do educational consultations and you can check the calendar at chrismasterjohnphd.com/consultations.

    2. For practical purposes choline and betaine are close enough to be treated as 1:1. Betaine HCl is 75% betaine.

  3. Chris – to clarify what you have stated in your video, if one were to have a slow COMT then providing the body with a steady supply of methyl groups (MSM, Methyl B12, methionin, Methyl folate for instance) plus the needed cofactors; B6 and Mg+ will help speed up this gene?
    Thoughts on taking Vit C to breakdown dopamine during a rumination spell???

    1. If I remember correctly, I heard a YouTube lecture state that one should take bioavailable forms that are a step ahead in the pathway of the methyl so as to not innundate the system. Maybe, Dr. Masterjohn can elaborate or confirm this.

  4. Any additional hints on further metabolizing estrogen, or lowering estrogen in males? My estrogen seems to be stubbornly stuck on the mildly high side.

    1. I take Femguard by Designs for health and Estrovite by Apex Energetics. I’ve noticed a shedding of fat around my hips and thighs with these two products.

  5. Hello please can you send me an email with your email address so I can discuss about my COMT gene with you I need some advice. Thanks

    1. Did you read the transcript or watch the video? “Fast COMT” is not a problem that needs a supplement solution.

  6. “When nutrition is optimal, this just leads to personality differences: with low COMT activity, you’re better at focusing, but tend to ruminate on things rather than letting them go; with high COMT activity, you rarely get stuck in a rut, but you just as rarely sit down to focus on one single thing.”

    What you described is not ADD or ADHD. ADD/ADHD is more of a problem with executive functioning than attention (despite the name), and many people with these conditions actually vacillate between these extremes. It’s the inability to choose where to focus your attention, not a lack of attention in general. That said, dopamine is still thought to be related.

  7. Great article on the COM gene issue. I am +/+. The supplements/nutrients you mention are noted.. a little detail about what to take and dosing specifics would be much appreciated

  8. Hi Chris, love your work. I’ve read some papers that have suggested increased choline intake is associated with higher production of TMAO and cancer risk. If this is true, is there a way to mitigate the risk and still yield the benefits?

  9. Do these COMT genes affect methylation of dopamine in general? If you were ++ for both, would you be a higher risk for Parkinsons, for example, or any ofther conditon where low dopamine is a problem?

  10. Hi Chris, this is interesting stuff. I may have missed it somewhere but how exactly do you get your “glycine buffer in place?” Is it just a matter of ingesting enough glycine? It applies to my son who is in the 25% with high COMT. He also has had a concussion so the difficulty with focus and attention is especially big right now.

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