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Why Aspirin Goes Best With Bicarbonate and Glycine

Most over-the-counter anti-inflammatory drugs carry a risk of causing food intolerances and chronic, low-grade inflammation. Aspirin is an exception. But this is why it’s best taken with bicarbonate and glycine. IMPORTANT NOTE: Give 30-60 minutes between any dose of bicarbonate and aspirin to avoid hurting your stomach. Tune in to learn more!

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  1. This is so great. I have a terrible reaction to aspirin – hallucinating and terrible anxiety. Niacin is a real positive for me but I don’t want to use Niacin as a drug and it looks like glycine must be the solution to this. Thanks for posting stuff like this for those of us who can afford a lot of private consults.

  2. Chris,

    I am assuming the baking soda and glycine should be taken in conjunction 30-60 minutes before the aspirin dose? Also, how would you use this strategy if you wanted to take your aspirin dose after eating a meal?

    Thanks for all the great info!

    1. It could lower your ionized calcium levels, which is bad for bones and nervous system, and it could predispose to urinary tract infections and certain types of kidney stones.

      6.4-6.8 is ideal post-meal range in normal health.

      7-8 is good temporarily while on aspirin.

  3. This article was extremely enlightening. I struggle with autoimmune issues, and the most noticble sign of a flair is skin issues. Which happens within a few days or taking an NSAID.

    Do you think there would be any benefits to taking a low dose aspirin to help with autoimmunity?

    I know things like curcumin are the main go to herbs but I fear the issues with it stimulating TH2 it feels safer to avoid.

    Seriously, awesome post! Would love to see some autoimmune articles!

    Keep up the great work! Totally grateful. You should have a donate button!

  4. I was fascinated by your suggestion regarding the utility of glycine and bicarb as supplements to improve the safety of aspirin. I was equally fascinated by the suggestion that aspirin could be a potentially safer anti-inflammatory than the newer traditional OTC NSAID’s. I became aware of NSAID’s danger re kidney and heart disease several years ago. The possibility of NSAID’s contributing to chronic lower grade inflammation and the dual functioning of the COX enzyme is new to me and I haven’t been able to find answers online regarding it. Will you please expound more upon the different effects of ASA and NSIAD’s? Much thanks for sharing your understanding

    1. If you Google my name and COX you should find a couple of articles where I’ve covered it in a little more detail. I will do more in the future. Thanks!

  5. As always, very intesting.
    You say this: salicylate acts just like all the other anti-inflammatory drugs by blocking COX. Then you detail using bicarbonate to speed excretion of salicylate by lowering urine PH.
    So are regular COX inhibitors also salicylate driven? Or at least something that is affected by urine PH. What I’m wondering is what would happen if your urine PH was low and you were taking tylenol or ibuprofen, would their affect be less because of the higher PH? Could this explain some of the dose variation that certain people seem to have?

    1. By raising urine pH, not lowering.

      No, most NSAIDs are not salicylate. I don’t know how urine pH affects the other NSAIDs or acetaminophen.

  6. Please keep me posted. I have information and nerve pain. I have been taking Ibuprofen and Gabapentin. I don’t like taking either, but I need my rest at night.

  7. Thank you, I was literally just wondering about this. I’m needing to be on something anti-inflammatory for awhile due to nerve pain and not wanting to do ibuprofen for too long. Incredibly useful information.

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