Mastering Nutrition Episode 15: You Asked Me Anything About Heart Disease, Facebook Live, 06/16/2016

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The Facebook Live episode where Chris Masterjohn, PhD, answered questions about saturated fat, polyunsaturated fat, ApoE E4 genetics, carbohydrate, insulin, PCSK9, the LDL receptor, thyroid hormone, blood cholesterol, the total-to-HDL-cholesterol ratio, other blood lipid measurements, prehypertension, and much more.

This past Thursday, we all showed up live on Facebook so you could ask me anything about heart disease. Here's the video, and the audio recording as a podcast. 

Don't forget this Saturday at 2:00 PM eastern time you can show up live again to ask me anything about methylation! Here is the full schedule of upcoming Facebook Live events. 

Listen on ITunes or Stitcher.
Click here to stream.
Right-click (control-click on the Mac) here and choose “save as” (“save link as” on Mac) to download.
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Read the show notes.
Leave a comment.

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Read on for the shownotes.

Show Notes for Episode 15

Here is what you will find in the episode (please note that the times are for the podcast; they will be similar but slightly different for the video because the video and podcasts have different introductions):

4:00 Introduction about the pathogenesis of atherosclerosis
12:10 Should we micromanage the intake of specific saturated fatty acids to prevent heart disease?
26:23 Should we use our ApoE genotype to help decide what to eat?
36:05 Why the total-to-HDL-cholesterol ratio is still my favorite lipid-based predictor of heart disease risk.
37:34 The importance of fat-soluble vitamins
42:39 Interpreting total cholesterol and the total-to-HDL-cholesterol ratio along with thyroid and sex hormones to understand cholesterol metabolism.
47:50 What do statins do to your body?
49:09 Why do different HDL particles differ in their protective properties? I discuss the role of vitamin E.
52:04 Can heart disease be reversed?
58:39 Does pre-hypertension directly contribute to heart disease, or is its association with heart disease a reflection of a common underlying cause for both?
1:02:54 What are the most important markers to look at and which are most modifiable?
1:07:22 The regulation of PCSK9 by insulin and inflammation, with an evolutionary context for why it is regulated this way.
1:13:17 Do Americans consume too much calcium?
1:18:15 Using essential oils to prevent or treat heart disease.
1:21:58 How do we approach whether to use diet and lifestyle or to use medication?

Links Related to Episode 1

Good Fats, Bad Fats, Separating Fact From Fiction

Whole Health Source: The Tokelau Migrant Study

Follow me on Snapchat (chrismasterjohn) for some streaming 23andMe hacks (for example, ApoE)

The Total-to-HDL-Cholesterol Ratio — What Does It Mean?

Fat-Soluble Vitamins and Heart Disease

My AHS2014 Presentation: Resolving the Vitamin D Paradox

Joel Salatin and I debated Neal Barnard and Gene Baur on Intelligence Squared: Don't Eat Anything With a Face

The Central Role of Thyroid Hormone in Governing LDL Receptor Activity and the Risk of Heart Disease

Mastering Nutrition Episode 11 on Insulin and Body Fat Regulating Thyroid Hormone and LDL Receptor Activity

My letter to the Journal of the American College of Cardiology about the role of vitamin E in determining the anti-inflammatory properties of HDL particles

My Examine.Com Research Digest Editorial on the Importance of Insulin and Carbohydrate to Antioxidant Defense

Regulation of PCSK9 in response to insulin and inflammation

The lipoproteins, very basic intro

Root Canal Coverup by George Meinig

The Kresser Institute

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  1. Hey Chris. Any chance you are going to do a podcast on your approach to treating thyroid issues? You have discussed the importance of the thyroid many times and I would be curious to hear your approach to getting to the underlying causes, as well as potential treatments.

    Do you have any resources you recommend on the topic? Or, maybe you have discussed it in depth elsewhere and I have missed it.


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