Chris Masterjohn is live on facebook and they asked him anything about methylation

Mastering Nutrition Episode 17: You Asked Me Anything About Methylation, Facebook Live, 06/25/16

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Chris Masterjohn is live on facebook and they asked him anything about methylation

This past Saturday, we all showed up live on Facebook so you could ask me anything about methylation. Here’s the video, and the audio recording as a podcast. 

Don’t forget this Wednesday (at the time this post is published, that's tomorrow!) at 5:00 PM eastern time you can show up live again to ask me anything about vitamins A, D, and K! Here is the full schedule of upcoming Facebook Live events. 

You can watch the video on Facebook using this link.

Listen on ITunes or Stitcher.
Click here to stream.
Right-click (control-click on the Mac) here and choose “save as” (“save link as” on Mac) to download.
Subscribe in your own reader using this RSS feed.

Read the show notes.
Leave a comment.

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Read on for the show notes.

Show Notes for Episode 17

In this episode you can find the following:

  • 0:00 Intro, announcements about ChrisMasterjohnPhD.Com and my experience so far with US Wellness Meats liverwurst.
  • 9:05 Figuring out apparently choline-induced headaches
  • 12:20 An MTHFR mutation (e.g. C677T) could, even with normal homocysteine, be taxing your choline supply and causing you to waste away glycine into your urine. Boosting choline and glycine supply, and, perhaps most surprisingly, even supplementing with creatine, could help.
  • 30:03 Using SAMe supplementation to diagnose methylation issues.
  • 34:12 Choline and fatty liver disease
  • 36:28 Why serum B12 shouldn't be used as the primary marker of B12 status and how to get MTHFR genetics tested
  • 39:03 COMT mutations regulating (via dopamine) the balance between mental stability and mental flexibility, whether 5-methyl-folate supplementation could hurt mental health in those with low MTHFR activity but high COMT activity. Potential relation to obsessive compulsive disorder (OCD).
  • 55:36 How to get choline if you're allergic to eggs?
  • 57:33 Strange ammonia scent in the urine
  • 1:01:29 If someone eats a diet low in muscle meat, is it still important to eat collagen-rich animal foods?
  • 1:06:38 My serum B12 is off the charts and I'm not even taking a supplement. What gives?!
  • 1:09:32 MTHFR mutation, no gall bladder, and high liver enzymes on a high-fat diet: choline support seems in order, but rethinking the high-fat diet in this particular case is also wise.
  • 1:11:48 My thoughts on fasting for general health
  • 1:14:00 Post-traumatic stress disorder (PTSD)
  • 1:15:41 Thyroid autoimmunity
  • 1:20:24 Nutritional support for nitric oxide production
  • 1:25:13 Supporting glutathione status
  • 1:27:26 What is the best selenium supplement to take?

Here are relevant links:

  • My posts on choline and fatty liver disease
  • Meeting the Choline Requirement
  • Resources for measuring methylation genetics: 23andMe, MTHFR Support, Genetic Genie, NutraHacker (ignore all of the recommendations in the right column of the report)
  • The Pursuit of Happiness, my article on methylation of dopamine and the balance between mental stability and flexibility
  • MMA test for vitamin B12 status
  • Selenocysteine — This is my preferred form of supplemental selenium. For someone taking it as extra insurance, I believe one capsule every two days is a reasonable dose. For someone with evidence of selenium deficiency (ideally this means plasma glutathione peroxidase activity or plasma selenoprotein P are low), I think it is reasonable to take one capsule every day. Higher doses should require supervision and regular monitoring of selenium status.


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  1. Sorry if I misunderstood but are you aware of Dr Walsh? Until I read his work I didn’t realize that supplementing with folate and B-vitamins will have a detrimental effect if you’re an undermethylator; whereas it’s the cure for overmethylators.

    Undermethylators need to supplement with Sam-e and methionine
    Overmethylators need to supplement with folate.

    This made all the difference for me. Here’s a link to his blog:

  2. But I would love to know why taking more choline / eating choline (and getting more vit D) gives me terribly dry, chapped lips.

  3. My family and I have been having problems with high choline foods (particularly liver) and also with supplemental choline (and betaine, and other methyl donors like methylfolate). I recently discovered that it was due to vitamin D deficiency caused by taking A and D (along with K) in too high a ratio of A:D.

    I calculated ages ago that a 25:1 ratio worked best for us, which I think fits with roughly what you’d get from eating a WAPF type diet. The only fat we tolerated at the time (white palm oil) had no fat soluble vitamins and we were unable to tolerate liver, so that makes sense. However, we subsequently managed to switch to beef dripping and started eating some liver – but failed to adjust the ratio of A:D we were taking.

    To my surprise, adding more vit D has stopped one of my sons soiling himself every time he eats high choline or takes choline supplements, and has stopped the other from waking in the night screaming and punching me every time he eats more than 1/4 tsp liver.

    It actually turns out we seem to have had a pretty bad choline AND vitamin D deficiency, but we did badly with supplementing / eating more of either because we weren’t doing the two together. My eldest has been suffering from increasing constipation, to the point where he only had one bowel movement a week despite taking loads of magnesium. Since giving more vit D along with eating more liver, he has had 5 days in a row of bowel movements, which is great progress.

    I wanted to mention in case others are having a problem with choline due to lack of vit D.

    Thanks so much for your site, Chris – it has been hugely helpful to me in understanding more about lots of aspects of our health journey.

    1. Hi Katie,

      Thank you for taking the time to write this post, it might have greatly helped me on my lifetime chapped lip and fatigue problem. I have been taking methyl donors etc for some time now relating to mthfr a1298c and NOS homozygous mutations. Every time I add DMG that helps with my speech it makes my lips ten times worse. But I know I need it. Ok it’s not choline but the same principal may apply so it’s worth a shot with the vit D. Thank you!

      From another Katie!

  4. Hi Chris,
    I have 2 questions that were not answered.
    I have MTHFR C677T variant plus five more, 2 of which are homozygous. Why did I only get seriously ill after 45? Shouldn’t I have been ill my entire life? I was not blessed with health, but managed to 45 and now can’t even function. Was the mutation expressed later in life or the accumulation of the health problems created by undermethylation kicked in later in life?
    My MMA is normal, should not it be elevated if I have methylation issues? My homocysteine is elevate, as well as serum ferritin. Thank you.

    1. Hi Sam,

      If a problem is moderate rather than severe, it is quite normal for it to show up later in life.

      No, those mutations have nothing to do with MMA, which elevates in B12 deficiency.

      Elevated homocysteine indicates deficient methylation support, most likely.

      Elevated ferritin could reflect iron accumulation or could reflect inflammation. You should follow it up with hsCRP and a full iron panel. The latter should include total iron-binding capacity, unbound iron-binding capacity, and transferring saturation.


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