If you’re concerned about your cholesterol, or confused about what to do, this episode is for you. In this episode, I list the four key factors that control blood cholesterol levels and outline the simplest dietary or lifestyle changes we can make to have the biggest impact.
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Show Notes for “What to Do About High Cholesterol”
In this episode, you will find all of the following and more:
00:33 Cliff notes
09:22 Targeting the low-hanging fruit
11:50 The total-to-HDL-C ratio as a fingerprint of low LDL receptor activity
13:20 Other markers such as particle size, particle count, and ApoB as fingerprints of low LDL receptor activity
16:30 The four factors that control the LDL receptor
18:50 Intracellular free cholesterol (effects of dietary fiber, cholestyramine, statins, and polyunsaturated fatty acids or PUFAs)
20:37 Thyroid hormone (effects of micronutrients, body fat, and carbohydrate intake)
23:50 Insulin (via PCSK9, effects of the fasting-feeding cycle and carbohydrate intake)
27:00 Inflammation (via PCSK9, effects of acute infection and chronic inflammation)
29:15 Practical approaches to maximizing LDL receptor activity
29:22 Nutrient-dense whole food diets
34:00 Thyroid disorder
37:15 Adrenal stress, circadian stress, inflammatory stress
39:05 Insulin resistance, body composition, and fatty liver disease
42:00 Weight loss will improve insulin sensitivity, and for many a low-carb diet is a tool to achieve that, but in an insulin-sensitive person, carbohydrate stimulation of insulin has a powerful beneficial effect on LDL receptor activity
46:20 Inflammation and PCSK9
47:00 C-Reactive Protein levels, body composition, diet quality, and exercise
49:25 Replacing fat with carbohydrate
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Episode 25 on what causes insulin resistance at the cellular level.
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