MTHFR, Depression, Irritability, and Anxiety | Masterjohn Q&A Files #186

Question: MTHFR, Depression, Irritability, and Anxiety

So, if someone has an MTHFR snip, they don't have enough methylfolate. And so if they're treating it with methylfolate, the methylfolate causes the depression, irritability, and anxiety, then that's one thing. Whereas, if they have the MTHFR snip, they're not doing anything about it and they have depression, irritability, anxiety, that's another thing. So, if they're not doing anything about it and they have those problems, then it's probably from under-methylation. If they're supplementing methylfolate and that's causing the depression, irritability and anxiety, then my guess is that that is a temporary transient over-methylation state. That is a result of the body being adapted to a low methylfolate state and suddenly switching to a high methylfolate state. And I think the key to getting through that is to take small doses of the methylfolate and equilibrate to the lowest dose.

This is my “Start Here for Methylation” page I mentioned:

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at You can sign up for a consultation at

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

How to watch it:

How to share it and show it love:

You may also like

Leave a Reply

Your email address will not be published. Required fields are marked *