Short answer: Low or low-normal alkaline phosphatase may raise the plasma B6 level over the cellular level. Tryptophan metabolites in urine reflect the B6 requirement for the kynurenine pathway, and this requirement increases with more estrogen, more inflammation, or a higher protein intake. This episode was cut from the original Q&A session that you can find here. …
Short answer: 4-6 hours after a meal the small intestine is emptied and the insulin-to-glucagon ratio declines; 25 hours after, hepatic glycogen is emptied; 5 days later the brain is adapted to ketones and gluconeogenesis reaches its minimal level. Moving from one to the other cannot occur with a small piece of signaling like the bite …
Short answer: Probably not. Animal studies showing a difference use huge doses in an unrealistic context. Human studies show they don’t at doses used. Human effect on PSA is vulnerable to regression to the mean and thoroughly unconvincing. This episode was cut from the original Q&A session that you can find here. DISCLAIMER: I have a PhD …
Short answer: Trust the CGM. HbA1c is confounded by red blood cell turnover and fructosamine 3-kinase activity. This episode was cut from the original Q&A session that you can find here. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing …
Short answer: You should be able to see changes on imaging within a few weeks if your approach is working well, but ultimately this is entirely dependent on how negative your “delta fatty liver = (fat in) – ((fat out) + (fat burned))” equation is. This episode was cut from the original Q&A session that you …
Short answer: 25(OH)D is 1000 times weaker at activating the VDR than 1,25(OH)D, but 1000 times more abundant. This is why I advocate measuring both, and ultimately believe we need to create a calculated index of “biological vitamin D activity” from them. This episode was cut from the original Q&A session that you can find here. DISCLAIMER: …
Short Answer: Measure this against whether it increases your likelihood of burning. If it does, it’s probably a bad thing, but if it doesn’t, or if it lowers your risk of burning, that’s a good thing. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of …
Short Answer: Vaccination shouldn’t change the vitamin D requirement. Quarterly testing makes sense for someone who has never tested before or who wants to make sure they stay in range during COVID, but generally testing yearly around the mid-point of seasonality for you, once you know your variation, is plenty. Watch the video or listen …
Short Answer: BH4 is expensive and requires very high doses, so if the problem is modest it can much more easily be solved by taking tyrosine. Watch the video or listen to the podcast with the links below. You can obtain a full transcript of the episode by signing up for the Masterpass at https://chrismasterjohnphd.com/q&a …
Short Answer: While the body will tend to use TMG for methylation in the fasting state, it is normally found in food, so you should be able to absorb it with meals and hold on to it for later use, much as we do with folate. Watch the video or listen to the podcast with …