Why would someone not tolerate methyl donors even if they need them? | Masterjohn Q&A Files #306

Short Answer: I believe most methyl donor intolerances are a result of deficiencies in the glycine buffer system, which requires glycine, vitamin A, fasting (glucagon), androgens, riboflavin, unmethylated folate (THF), and iron. No one should expect to tolerate 30 milligrams of folate, however, and there is almost never a reason to use doses that high.

Balancing Vitamin C and Glutathione: Final Report

Maintaining good GSH status is always important to protect high-dose C from generating oxalate and may often be important for preventing it from acting as a pro-oxidant. Cancer is an exception. In my preliminary report, I voiced the concern that high-dose vitamin C could deplete glutathione and worsen nitric oxide toxicity when not properly balanced with …

Recording and Transcript of the June 16, 2022 AMA

SIBO; CGM/HbA1c conflicts; vitamin C, copper, and histamine; reishi, curcumin, and testosterone; magnesium problems; vitamin toxicity; fat malabsorption; tinnitus; baking glycine; much more. Time Stamps 03:41 What to Do About Persistent SIBO? 20:03 If your CGM conflicts with your HbA1c 27:30 Are there toxicity concerns for vitamin C and copper used for histamine? 33:55 Are there toxicity concerns for …