How to slow or reverse graying of hair? | Masterjohn Q&A Files #321

Question: How to slow greying of hairs and potentially reverse it? Short Answer: What works for any given individual will likely be to find the weakest link and fix it, from among the following systems: the signaling of energy abundance (body fat, insulin sensitivity, thyroid hormone, adequate protein, individualized meeting of carbohydrate needs, good management of psychosocial …

Phosphatidylcholine and TMAO | Masterjohn Q&A Files #312

Question: If I’m at risk of heart disease and phosphatidylcholine increases my TMAO, should I stop the supplement? Short Answer: On a scale of one to ten, my concern about TMAO and cardiovascular disease is a three. There are thousands of things that should be given equal weight as potential contributors to heart disease, but TMAO gets …

Why would someone not tolerate methyl donors even if they need them? | Masterjohn Q&A Files #306

Short Answer: I believe most methyl donor intolerances are a result of deficiencies in the glycine buffer system, which requires glycine, vitamin A, fasting (glucagon), androgens, riboflavin, unmethylated folate (THF), and iron. No one should expect to tolerate 30 milligrams of folate, however, and there is almost never a reason to use doses that high.

Balancing Vitamin C and Glutathione: Final Report

Maintaining good GSH status is always important to protect high-dose C from generating oxalate and may often be important for preventing it from acting as a pro-oxidant. Cancer is an exception. In my preliminary report, I voiced the concern that high-dose vitamin C could deplete glutathione and worsen nitric oxide toxicity when not properly balanced with …