Question: What should someone with FH eat if they also have prediabetes? So first of all, it’s a separable component of the diet so you need a low-saturated fat, low-cholesterol diet without necessarily eating a low-fat diet. Then second of all, the effect of that on blood lipids is dependent on the healthfulness of your …
Question: How should I take zinc if it makes me nauseous? As far as I know, there’s no relationship between the nausea and zinc deficiency. I could be wrong, maybe there’s research on it I haven’t seen or it could be not researched but I don’t think there’s a connection. My guess would be that …
Question: Can familial hypercholesterolemia be managed without statins? I think there’s the general perspective that there’s no point in having LDL-C be any higher than 50; therefore, since it doesn’t matter, let’s provide a sufficient margin of error where we’re real confident that getting it down to 100 is great and so why not get …
Question: Is this a biotin deficiency? Beta-hydroxyisovaleric acid is well-established to be the most sensitive marker of biotin status. And actually typically it’s done after leucine challenge, which is, no one does that. And so, generally in my experience, the way they have the reference ranges set on that should, on the ones that do …
Question: Why do vitamin E requirements stay elevated for four years when we stop eating PUFA? None of this really proves that long-term vitamin E status is compromised, and that will make the clinical effect of PUFA be net negative after four or five years. But it does show you that the general relationship between …
Question: How long should our fasting windows be? I think someone who eats three meals a day and no snacking is doing a form of intermittent fasting that most people aren’t doing. And I don’t even have a basis for believing whether that is superior, inferior, or the same as one meal a day in …
Question: What is the value of third party genetic reports? There are very, very few genes where we have really good information on how they impact nutritional requirements, but we have many, many, many genes where we have decent information on what they do mechanistically and where we can speculate things that might be helpful. …
Question: What is the value of the oxidized phospholipids test? It’s interesting to measure, but we don’t have real strong data on its correlation to disease risk. And we also don’t really know how much it reflects the oxidation of lipoproteins in the subendothelial space, which is what matters. If you would like to be …
Question: Can NADH supplements cram more NADH into the system? The NADH will be hydrolyzed to something along the lines of nicotinamide riboside, it will be absorbed and it will act like nicotinamide riboside does, which will increase the amount of nicotinamide stored in the liver for release to the tissues. And that will help …