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What’s a better nasal spray, Sterimar or povidone-iodine? | Masterjohn Q&A Files #151

Question: What’s a better nasal spray, Sterimar or povidone-iodine? It’s hard to say. So the Povidone-iodine obviously has some contraindications and it has contraindications mostly because it’s been so commonly used in a medical setting and therefore has so much known about its safety and risk profile and I don’t have any particular reason to …

Do postmenopausal women need to worry about iron overload? | Masterjohn Q&A Files #150

Question: Do postmenopausal women need to worry about iron overload? Generally, it’s not men who are necessarily predisposed to iron buildup. It’s men with some genetic predisposition to that, so maybe less than 10% of men. But yeah, postmenopausal women with the same genetics will, like men, be vulnerable to that. When you stop menstruating, …

Should NAC supplementation be pulsed? | Masterjohn Q&A Files #149

Question: Should NAC supplementation be pulsed? So, yes, boost glutathione. It might bring glutathione down. It’s speculative that you could pulse it to avoid that. But even supplementing oral glutathione for 6 months was shown to not affect glutathione production. And certainly, oral glutathione is going to have more of a negative feedback loop than …

Why would my threonine levels be low? | Masterjohn Q&A Files #148

Question: Why would my threonine levels be low? The two things I can think of are increased gluconeogenesis and increased conversion of methylglyoxal, both of which I would expect to be driven by a low carbohydrate diet. Then of course, it could also be not enough protein consumption. But if it’s why threonine is being …

What’s the best alcohol to microdose? | Masterjohn Q&A Files #147

Question:  What’s the best alcohol to microdose I prefer red wine on a taste, and tradition, and aesthetic basis. Just for background, I think  Half a drink to a drink a day is probably the net maximal benefit for alcohol and that can be averaged. It doesn’t have to be every day. And that’s the …

What’s the best nutrition for panic and anxiety? | Masterjohn Q&A Files #146

Question:  What’s the best nutrition for panic and anxiety? Methylation is overwhelmingly important. I do think that other factors impacting dopamine can be relevant in the sense that the main way that methylation regulates mental rigidity is through decreasing the pool of tonic dopamine, which favors mental flexibility. And so, you can also favor mental …

What determines the absorption of nutrients? | Masterjohn Q&A Files #145

Question:  What determines the absorption of nutrients? This is a gigantic question because what determines the absorption of any given nutrient is independent for that nutrient. And so, it’s different for every nutrient. And we just don’t have that level of data to drive modeling of absorption of other nutrients in an accurate way. If …

Do low serine levels require IV supplements? | Masterjohn Q&A Files #144

Question:  Do low serine levels require IV supplements? You’re probably just depleting serine through the CBS pathway and just eat more protein and consider supplementing glycine or collagen along with it. I don’t see why that would require IV supplements.  If you would like to be part of the next live Ask Me Anything About …

How to fix high iron and calcium, low copper and magnesium, without blood donation? | Masterjohn Q&A Files #143

Question: How to fix high iron and calcium, low copper and magnesium, without blood donation? Your only options for decreasing iron levels are to eat a low meat vegetarian diet high in vegetables, nuts, seeds, and whole grains. That’s probably your best bet. But the thing is, a very vegetable rich diet is gonna be …

How much time should separate my zinc supplements and nut consumption? | Masterjohn Q&A Files #142

Question: How much time should separate my zinc supplements and nut consumption? So, phytate primarily inhibits absorption of zinc and iron. I think you’re gonna have a much lower probability of zinc encountering phytate if you take the zinc 2 hours after eating the phytate than if you take the zinc while you eat the …