Ketones have a dark side: ketoacidosis. And it does NOT only happen in diabetes. Ketoacidosis is a serious and life-threatening medical condition wherein ketones accumulate to such high levels that they overwhelm the body’s natural buffering capacity and sink the pH of the blood to dangerous and possibly fatal levels. Ketoacidosis is most often associated …
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Ketone homeostasis has two central objectives: 1) keep ketone levels high enough to feed the brain, and 2) keep ketone levels low enough to avoid the serious and life-threatening condition of ketoacidosis. While proportion of circulating ketones taken up by skeletal muscle, heart, and other tissues during fasting is initially high, these tissues limit their …
The physiological purpose of ketogenesis is to spare the loss of lean mass that would otherwise occur during prolonged fasting. Meeting the glucose requirement of the brain entirely by gluconeogenesis from amino acids would cause us to lose 2.2 pounds of lean mass every day. This would cause us to die much more quickly from …
The production of ketones in the liver frees up coenzyme A (CoA) that would otherwise be captured in the accumulating acetyl CoA, and the conversion of acetoacetate to beta-hydroxybutyrate frees up NAD+ that would otherwise be trapped as NADH as the production of NADH in beta-oxidation exceeds that oxidized in the electron transport chain. This …
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In August of this year, 25-year-old bodybuilding mom Meegan Hefford was found unconscious in her apartment, brought to the hospital where she was declared brain-dead, and died soon after. The cause? “Too much protein before competition,” according to the New York Post. She had recently doubled her gym routine, started dieting, and begun slamming protein …
The Mastering Nutrition podcast will be back soon, and this month Paleovalley is sponsoring it. And with their sponsorship comes a HUGE discount to you. I’m proud to have them on board as I’m a big fan of their beef sticks. I use them as a convenient yet nutritious snack. They are made from 100% grass-fed …