Introducing Chris Masterjohn Lite

MTHFR or not, this is the minimum that EVERYONE should be doing to support methylation, boiled down into five simple rules.

Tune in to learn the rules!

How to watch it:

How to share it and show it love:

This episode is brought to you by Ancestral Supplements. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, bone marrow and more… in the convenience of a capsule. For more information or to buy any of their products, go to

This episode is brought to you by Testing Nutritional Status: The Ultimate Cheat Sheet. Everything you could ever need to know to optimize your nutrition, all in one place. Easier to find and use than ever before. Get your copy at Use the code LITE5 to get $5 off.

Want a Transcript?

CMJ Masterpass holders can access the transcript here.

Transcripts make it easier to use the information. You may just prefer to read. But having transcripts and video or audio can massively increase your productivity. For example, you can listen while you are washing the dishes, commuting to work, or doing other menial tasks, getting familiar with the material and scanning for things you want to learn more about. Then you can come back and keyword-search the transcript for the exact things you want to master in more detail.

To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated:

You may also like


  1. I am a pescatarian, although I don’t eat much fish (about one serving salmon/week) and very little grains. Primarily whole foods. My bloodwork came back saying MCV is borderline high (97.5) but since the lab puts the cutoff at 100, my doctor says not to worry. RBC is also low-ish but not below the cutoff, so again with the doctor – not concerned. I would like to try supplementation to improve these numbers. I was thinking methylated (haven’t been tested for MTHFR but just in case, right?) folate and b12. I also have started putting nutritional yeast on basically everything. Is there anything else I can do as long as my doctor doesn’t think it needs treatment?

  2. Hi Chris, My kids reacted badly to methylfolate supplementation – became ‘brittle’ emotionally and more depressed. This got me onto the Walsh Approach. They responded well to ‘undermethylator’ supplements. Could you explain possible reasons why they would have reacted badly to methyfolate supplementation? As per the Walsh Approach they have been eating a low folate diet since that time (2015).

    1. Without knowing a lot more I’m not sure. My guess is there’s something else missing for it to have that effect. It could relate to glycine or B12 interactions.

      1. P5P (with B2), B6, Magnesium, Vit C., L-Methionine. B12 was also recommended but as blood tests indicated it was really good I didn’t include. Also zinc as they tested low, and high for copper and ceruloplasmin. Youngest takes 5HTP to help get to sleep. I have over time added in Creatine. Since that time – 2015 – I have had them tested and have treated based on results of tests. E.g. – Urinary Organic Acids, Hair Mineral Analysis, G-MAP Stool Analysis, SIBO Breath Test. Youngest also has intolerances to gluten, casein, histamines, and salicylates. Without going into too much detail they are currently on a gut healing & detox (to reduce high aluminium, copper, … levels) protocol which I hope will reduce/remove the intolerances – especially histamines and salicylates. I have them on an amino acid mix which includes creatine, glycine, lysine, proline, and glutamine. Based on reading your methylation info I am increasing choline and adding TMG – and possibly stopping methionine, and hopefully being able to gradually add in more folate. I would love to be able to increase folate is diet. Legumes are okay on low salicylate and histamine diet.

      2. Here is a bit from ‘Nutrient Power’ by William Walsh. “The problem was resolved in 2009 with the discovery that methyl and folate have opposite epigenetic impacts on neurotransmitter reuptake at synapses….. The genetic expression of transporters is inhibited by methylation and enhance by acetylation…. The net result is that activities of serotonin, dopamine, and other neurotransmitters are strongly influenced by the methy/folate ratio….

    2. A bit more from the book – In many cases genetic expression depends on competition between acetyl and methyl groups at histone tails…..Attachment or removal of methyl and acetyl at histone tails is dominated by enzymes called methylases, acetylases, demethylases, and deacteylases – NOT by the amounts of methyl and acetyl present…..A good example is niacinamide (vitamin B3) that reduces the activity of sirtuin, an important deactylase enzyme. In another example, folic acid impacts methyl levels at histones. It’s interesting to note that folates increase methyl levels in tissues and the bloodstream, but they reduce methylation at certain histones that regulate gene expression….

      1. I am also in the same boat. I did the whole body histamine test recommended by Dr. Walsh’s protege, Dr. Mensah, and subsequently had a session with him. He unequivocally diagnosed me as undermethylator. He also did NOT suggest methylfolate. Instead, he recommended l-methionine and SAM-e. Wonder what Chris’ take is on this.

  3. Great article, Chris!

    Quick question: Does the b12 digestion peculiarity apply to supplements as well? i.e. if i take a b12 supp with 9999% of the dv, i’ll still only absorb 100% of the dv ? Or do certain supplemented forms bypass this rule?

  4. Hello Cris, and thanks for a nice video.
    Could you explain (maybe in a video) why you prefer fresh vegetables instead of frozen

    Yours kindly

  5. I do have the MTHFR defect and have been misdiagnosed all my life.
    Fibromyalgia, (which symptoms all point to B vitamin deficiency and magnesium deficiency), digestive problems, you name it. At 63 years of age it feels hopeless. I am having trouble with pain, weakness, nausea and absolutely no appetite. All your suggestions regarding nutrition are sound, but where I am at now seem impossible. My primary care physician doesn’t have a clue and I am pretty much throwing in the towel. It is hard to heal when you can barely eat.

  6. Hey Chris! Great stuff as always. Question about eating clams for B12 at each meal. 8 grams per meal seems super easy and a small amount, but just curious if 8 grams wasn’t a typo 🙂 I imagine that’d be something like 3-4 clams?

  7. What can I do if I am glutamate dominant and cannot eat many foods containing high levels of glutamic acid, including spinach and broccoli. I also can not tolerate folate and glutathione because of their glutamate component. For the same reason, I can’t use glycine supplements. People who react to glutamate often react to glycine, which is me. My diet is so limited because of this issue (which was caused by a physician who prescribed high dose glutamine for nearly 8 months to “heal” leaky gut. It turns out, I have genetic defects that prevent conversion of glutamate to GABA. Any thoughts on how to correct this imbalance in GABA/Glutamate? (It’s severe. I only sleep 1-2 hours per night. It’s killing me.)

    1. I also have a glutamate/GABA imbalance, at its highest point it triggers a seizure for me (adult onset idiopathic seizures). I am very careful with methylation as 1) increased methylation/folate means increased histidine conversion to glutamate via FIGLU, and 2) folate itself has some polyglutamates in it.

      Things that are helpful for me:
      – B6 in the form of P5P (for the glutamate-GABA enzyme)
      – magnesium (I believe helps with glutamate receptors)
      – avoiding folate supplements, and not overdoing liver/lentils/dark greens (but still eating them)
      – also read Chris’ article on here about glutamate/GABA balance

Leave a Reply

Your email address will not be published. Required fields are marked *