Mastering Nutrition Episode 14: I Came LIVE On Facebook So YOU Could Ask Me Anything, and THIS Is What Happened!

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Chris Masterjohn answered questions about saturated fat, obesity, inflammation, Ray Peat, Andrew Kim, sugar, antioxidants, Brian Peskin, tests for folate status, accidental gluten exposure, fecal IgA testing, protein, muscle mass, longevity, ketosis, carbs, the total-to-HDL-cholesterol ratio and the triglyceride-to-HDL-C ratio.

This past Saturday I went on Facebook Live for the first time ever so you could ask me anything about health, fitness, and nutrition. It was incredible! Thank you to everyone who came and asked questions!

Below you can watch the video or listen to the audio recording as a podcast.

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Read on for the show notes.

Show Notes for Episode 14

Here is what you will find in the episode (please note that the times are for the podcast; they will be similar but slightly different for the video because the video and podcasts have different introductions):

2:11 Is it the saturated fat that causes inflammation in animal models of obesity?
9:37 What do I think about Ray Peat’s and Andrew Kim’s views on sugar?
19:01 How essential are antioxidants in the diet? How much is too much?
29:38 What do I think about Brian Peskin’s work on “parent” essential oils?
31:16 What do I recommend as tests for folate status?
35:58 What would I recommend to recover from an accidental exposure to gluten?
44:33 What would I recommend telling a group of doctor’s interested in nutritional therapy about fats and cholesterol? (this includes a bit about choline)
54:49 How much protein should we eat to balance the priorities of muscle mass and longevity?
1:05:36 Is nutritional ketosis desirable for a healthy person, and is 100 grams of carbs per day enough?
1:19:51 What do I think about the potential for gluten withdrawal to help with neuromuscular issues and gross motor delays in children despite negative IgA tests?
1:24:22 Can someone’s triglyceride-to-HDL-cholesterol ratio be too low?

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  1. paymanz left this comment, that got lost in the migration from Blogger:

    chris can you please give your opinion about Azomite?

    it is recommended by weston A. price foundation as a mineral supplement.

    1. paymanz,

      I haven’t looked into it in a very long time and I don’t currently have an opinion on azomite.


  2. Thanks for hosting this, Chris! I hope to join in one one in the future.

    I have a question about a ketogenic diet. I finally decided to try it about 4 months ago just as an experiment. I actually was not a fan of it at all before and thought I would react very poorly as I am quite lean and active.

    However, after having followed it for over a few months, I am really liking it! My sleep has greatly improved (which I know you mentioned may be a negative for some on a lower carb approach) and so has my digestion. I also have zero cravings for carbs. I really enjoy my fattier meals with a good amount of protein.

    So my question is, knowing that this approach is probably not ideal long-term, is there anything I can do to make it as "safe" as possible? Any supplements you would recommend? Or, anything else you can think of?


    1. Hi Zach,

      The most straightforward way to deal with it would be to cycle onto a high-carb diet periodically. However, I listened to episode 82 of Sigma Nutrition Radio podcast where Jacob Wilson said he did a study where cyclic ketogenic diet produced worse body composition outcomes than straight ketogenic diet. So, doing that may nullify certain benefits of the ketogenic diet.

      One point of uncertainty that prevents a straightforward practical conclusion is this: what specifically is causing the benefit?

      Is it ketones? You can get ketones by including MCT oil and by exercising a lot even in the presence of plenty of carbohydrate.

      Is it carbohydrate restriction? If so, why? For example, if you are positively remodeling your gut microbes, you are likely experiencing a short-term benefit based on microbiota starvation that will eventually need microbiota refeeding to boost and maintain probiotic populations.

      Is it from increased adrenal output? That is likely to make you feel great until your adrenals give out.

      Is it from increased hypocretin expression in your brain? That is likely to make you feel great until homeostatic sleep pressure from adenosine building compensates for it.

      Is it because carbs themselves intrinsically need to be restricted to this degree to make you feel great? That would mean I need to radically rework how I think about this and my current answers might not be helpful.

      My suggestion would be to periodically measure your thyroid and stress hormones and stay on the diet only to the extent your hormones look great.


    2. Yes, I did see that study from Jacob Wilson. I have to admit that I am somewhat skeptical of some of his studies, however:/

      You pose some really good questions though. I would say I feel good because my sleep quality has greatly improved and so has my digestion. I have always had issues with digestion and have experimented with several approaches (including low FODMAP). Also, my calorie needs are quite high for my weight so I believe there is less digestive stress since fat is so calorically dense.

      I would say you are right about it being short-lived, however. I still feel great, but I am skeptical.

      Thanks for your input. I will keep these considerations in mind.

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