In this special interlude, I lay down the framework of the five core principles that make a good marker of nutritional status. This is to lay down the framework for a series of podcasts in the future about managing nutritional status for specific vitamins and minerals.
Since these core principles will be referred back to as a general reference in so many other episodes, this one has a special place outside of the sequence and you can reach it at any time with the easy-to-remember URL chrismasterjohnphd.com/interlude.
The episodes of the series are kept below, in the episode list.
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Show Notes for “What Makes a Good Marker of Nutritional Status?”
In this episode, you'll find all of the following and more:
37:23 Cliff Notes
09:25 Purpose of this podcast and its place in the upcoming series on managing nutritional status
11:54 What are the core principles?
12:05 Principle #1: We understand its biochemistry and physiology.
15:04 Principle #2: It has been validated against changes in nutritional status.
17:17 Principle #3: Sensitivity
17:52 Principle #4 Specificity
19:45 Principle #5: It must be interpreted in the overall context of other markers and the clinical and health history, current signs and symptoms, and diet and lifestyle analysis.
23:20 Example of principle #1: Spectracell vs dp-ucMGP as tests of vitamin K2 status.
27:20 Example of principle #2: 25(OH)D vs. calcitriol
29:20 Example of principle #3: transferrin saturation vs. ferritin
31:08 Example of principle #4: specificity of 25(OH)D and contexts where its specificity fails
32:50 Example of principle #5: distinguishing between calcium and vitamin D deficiencies as causes of 25(OH)D by testing PTH, calcitriol, and analyzing the diet and lifestyle
37:50 Shotgun approaches to nutritional testing
40:30 Whether to act on leads from shotgun approaches should depend on the risks and other costs of the actions.
Episodes of the Managing Nutritional Status Series
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