Dr. Chris Masterjohn talks about What to Do About Why You Should Eat Glutathione
Visit Us
Dr. Chris Masterjohn talks about What to Do About Why You Should Eat Glutathione

In episode 40, I explain why glutathione survives digestion and can be absorbed intact, and why supplementing with it or eating it in foods helps support your health.

Listen on ITunes or Stitcher.
Click here to stream.
Right-click (control-click on the Mac) here and choose “save as” (“save link as” on Mac) to download.
Subscribe in your own reader using this RSS feed.

Ways You Can Use The Podcast Notes

Read the show notes.
Search the database.
Get the supplement recommendations.
Check out the related links.
Leave a comment.

Want transcripts? Sign up for the CMJ Masterpass with this special link to get 10% off.

How to Share the Podcast and Show It Love

Share it on Facebook.
Like it on Instagram.
Retweet it on Twitter.

Show Notes for “Why You Should Eat Glutathione”

In this episode, you will find all of the following and more:

0:00:38  Cliff Notes

0:08:22  What is glutathione and why is it important?

0:13:33 Special Masterclass With Masterjohn Pro discount for Mastering Nutrition listeners

0:20:10  Why does glutathione survive digestion?

0:20:50  How is glutathione absorbed intact?

0:35:48  Evidence for intact absorption of glutathione

0:36:00  Oral glutathione increases tissue glutathione in animals when glutathione synthesis is blocked with BSO.

0:38:12  Glutathione crosses CACO-2 monolayers, a model of human intestinal absorption, even when glutathione breakdown is inhibited with acivicin and glutathione synthesis is inhibited with BSO.

0:39:25  Isotopically labeled glutathione fed to mice enriches labeled glutathione in liver and red blood cell with no signs of the label in glutathione digestion products.

0:40:30 Glutathione supplements increase glutathione status in humans.

0:41:10  Caveats and contrary evidence.

0:48:15  What form of supplement (sublingual, liposomal, regular) is best?

0:56:10  What are the best specific supplements?

0:58:10  What dose should you use, and how should you know if you should use it?

0:58:43 Anecdote: 1 gram of glutathione relieves laughing-induced wheezing.

1:02:50  Glutathione in foods: reduced glutathione, total glutathione, glutathione-reactive substances, net glutathione

1:08:25  Glutathione content foods is not the be-all end-all of whether a food boosts glutathione status or whether it's healthy, but it's notable and important.

The Glutathione Database

“Consuming Glutathione in Foods and Supplements” can be accessed with the easy-to-remember URL, chrismasterjohnphd.com/consumingglutathione. It contains discussions of the principles fleshed out here in greater detail, supplement recommendations, and a searchable database of glutathione in 285 foods.

Glutathione Supplement Recommendations

Jarrow Reduced Glutathionetaken according to the label directions for boosting glutathione status if you know or suspect yours is poor. Or, taken in 1000 mg doses up to three times a day for occasional immune support or relief from respiratory symptoms.

Core Med Science Optimized Liposomal Glutathione if Jarrow does not provide the desired effects. This is most likely to provide greater benefit if you have a metabolic disorder, an inflammatory condition, or are chronically restricting carbohydrate.

Links and Research Related to “Why You Should Eat Glutathione”

Twitter question about glutathione surviving digestion.

Protein Digestion and Absorption (free Google Book preview) from Physiology of the Gastrointestinal Tract (same edition on Amazon as in Google Book preview), which is now in a new edition.

Glutathione Transporters.

Uptake of glutathione intact in CACO-2 monolayers and orally in animals.

Oral glutathione increases tissue glutathione in BSO-treated animals.

250 mg and 1000 mg glutathione increases glutathione status in humans over 6 months.

A negative study using 1000 mg glutathione for one month.

A comparison of sublingual glutathione, regular glutathione, and N-acetyl-cysteine.

The case for liposomal glutathione

Other Links Mentioned in “Why You Should Eat Glutathione”

My MWM Pro classes

Regression to the Mean: How a Study Can Show Something to Be True When It's Completely False

Looking for regression to the mean is part of a broader approach to reading science papers. For my approach, see How to Read a Science Paper.

The Biochemical Magic of Raw Milk and Other Raw Foods: Glutathione

Why You Should Manage Your Glutathione Status and How to Do It

My antioxidant masterclass puts glutathione in context.

Search the site for glutathione to find other related content.

Visit Us


You may also like


  1. Hi Chris,

    I came across this Glutathione formula. Have you heard of it? If so, what are your thoughts on it. The formula itself doesn’t contain Glutathione but contains ingredients that help boost glutathione levels (or so the manufacturer says).


  2. The Richie study was done, I believe with the Setria brand glutathione. Is the Jarrow brand the Setria form of glutathione? Reason I ask is that I thought I had read that Jarrow had a different type of glutathione. Wouldn’t be prudent to use the form that the Richie study used, of course, unless further research shows there is something better to ingest. Thank you.

  3. Well I posted this on the other article, but i’ve just seen this and maybe its more appropiate here,

    Do you think rectal administration of reduced glutathione supplement would aid in absorption? I’ve read some at the skin-whitening crowd to use it that way.

    Placing the powder under the tongue for sublingual absorption, wouldnt be too harsh for the enamel if doing it everyday?

  4. Chris, what about down-regulation? If starting at a low level of endogenous glutathione, will down-regulation only happen when we eat too much glutathione and we go over the optimal level for the body? Or could down-regulation happen even if glutathione is lower than optimal, just because we are eating a lot of it?

    1. Ian, very complicated question that I would need to address separately with independent research, and I doubt it can be answered with an umbrella application to all cancers.

      1. ok. I’m guessing the “answer” is, in fact, relevant to everyone, in the sense that everyone is dealing with some level of malignancy, albeit generally controlled by the immune system – but would supplementing with extra glutathione increase the cancerous trend over time and tip the balance unfavourably eventually? So the implied point is that although glutathione seems to have some highly beneficial effects in the short term, is sustained supplementation a bad thing? Maybe it can be used very occasionally when really essential, but otherwise not?

        1. I strongly disagree with that. People without cancer should probably be doing the opposite of what people with cancer should be doing, as many things that feed cancer growth protect against its initiation. Search for my writings on T. Colin Campbell’s rat experiments for a great example of this.

          1. So would you not recommend it for prostate cancer or skin cancer?
            How about cancer stem cells?

Leave a Reply

Your email address will not be published. Required fields are marked *