Showing: 1 - 6 of 11 Articles

What Can Familial Hypercholesterolemia Mortality In the 19th Century Teach Us About Genetics?

by Chris Masterjohn Not much, simply because the data are so poor.  However, let’s take a look at some data for the very weakly supported hypothesis that people in the 19th century with familial hypercholesterolemia lived longer than other people and perform a little “thought experiment” to see what it could teach us about genetics if …

The New Genetics — Part I: How Our B Cells Create Their Own Antibody Genes

Among the cells of our immune system, the B cells make our antibodies.  Each B cell makes a different antibody.  We make an estimated one trillion different antibodies, giving us the capacity to respond to virtually any pathogen.   Even more remarkably, each of these antibodies reacts with a variety of different antigens (an antigen is …

The New Genetics — Introduction

The rapid advance of the sequencing of the genome of humans and other species has revealed how little we actually understand about how our cells operate. Consider this passage from the fifth edition of Molecular Biology of the Cell (2008, p. 207): Accurate gene identification requires approaches that extract information from the inherently low signal-to-noise …