Short answer: Low or low-normal alkaline phosphatase may raise the plasma B6 level over the cellular level. Tryptophan metabolites in urine reflect the B6 requirement for the kynurenine pathway, and this requirement increases with more estrogen, more inflammation, or a higher protein intake. This episode was cut from the original Q&A session that you can find here. …
Short answer: 4-6 hours after a meal the small intestine is emptied and the insulin-to-glucagon ratio declines; 25 hours after, hepatic glycogen is emptied; 5 days later the brain is adapted to ketones and gluconeogenesis reaches its minimal level. Moving from one to the other cannot occur with a small piece of signaling like the bite …
Short answer: Probably not. Animal studies showing a difference use huge doses in an unrealistic context. Human studies show they don’t at doses used. Human effect on PSA is vulnerable to regression to the mean and thoroughly unconvincing. This episode was cut from the original Q&A session that you can find here. DISCLAIMER: I have a PhD …
Short answer: Trust the CGM. HbA1c is confounded by red blood cell turnover and fructosamine 3-kinase activity. This episode was cut from the original Q&A session that you can find here. DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing …
Maintaining good GSH status is always important to protect high-dose C from generating oxalate and may often be important for preventing it from acting as a pro-oxidant. Cancer is an exception. In my preliminary report, I voiced the concern that high-dose vitamin C could deplete glutathione and worsen nitric oxide toxicity when not properly balanced with …
MASA chips launch today. Traditionally nixtamalized organic corn fried in grass-fed beef tallow. Full-bodied and perfectly salty. My friend Steve, who is the one who originally introduced me to the Essex Farm CSA that now supplies me with almost all my food, has invented a new tortilla chip that launches today! MASA chips are made …
Glycine problems, deficiency signs when lab tests are normal, the 3 phases of fasting & what kicks you out, lipoic acid & methylation, sulfur SIBO that always comes back, heat intolerance, and more. Time Stamps 00:01:57 Does folate have any function in the fed state? 00:03:30 How do I know if my digestive enzymes are helping or …
At what dose should we be concerned, and what can we do about it? Yesterday, I held a live Q&A with Masterpass members, and one of the questions that came up was whether we should be concerned about alpha-lipoic acid supplements hurting methylation as described in this rat study from 2010. After searching among the papers citing this study, the Examine.Com …
Why Nick Hiebert is wrong in using antagonistic pleiotropy to refute the ancestral health framework. I recently had a debate on Twitter Spaces with Nick Hiebert on the value of the ancestral health framework. I will publish this soon with my reflections. Here, however, I want to make an independent analysis that focuses narrowly on …
SIBO; CGM/HbA1c conflicts; vitamin C, copper, and histamine; reishi, curcumin, and testosterone; magnesium problems; vitamin toxicity; fat malabsorption; tinnitus; baking glycine; much more. Time Stamps 03:41 What to Do About Persistent SIBO? 20:03 If your CGM conflicts with your HbA1c 27:30 Are there toxicity concerns for vitamin C and copper used for histamine? 33:55 Are there toxicity concerns for …