Showing: 1 - 10 of 308 Articles

Statins Vs. Sulfur for Heart Disease | Masterjohn Q&A Files #307

Short Answer: From the trials, statins seem to reduce heart disease risk and total mortality, but it is impossible to separate this from conflicts of interest and industry funding. There are plausible mechanisms by which they may hurt mitochondrial function and promote soft tissue calcification. Dietary sulfur appears to lower cholesterol. While Lester Morrison showed 1500 …

Why would someone not tolerate methyl donors even if they need them? | Masterjohn Q&A Files #306

Short Answer: I believe most methyl donor intolerances are a result of deficiencies in the glycine buffer system, which requires glycine, vitamin A, fasting (glucagon), androgens, riboflavin, unmethylated folate (THF), and iron. No one should expect to tolerate 30 milligrams of folate, however, and there is almost never a reason to use doses that high.

Does whey protein hurt the kidneys or otherwise hurt our health? | Masterjohn Q&A Files #305

Question: Does whey protein hurt the kidneys or otherwise hurt our health? Short Answer: The main problem with too much protein, particularly animal protein, is that acidity may hurt the bones and increase the risk of calcium oxalate kidney stones, but this can be obviated by balancing it with organic acids, which have bicarbonate-sparing effects that are …

Does glucose handling in the brain decline with age? And if so, does this serve as a rationale to supplement with MCT oil to prevent cognitive decline? | Masterjohn Q&A Files #304

Does glucose handling in the brain decline with age? And if so, does this serve as a rationale to supplement with MCT oil to prevent cognitive decline? Short Answer: Energy metabolism in general declines across the body with aging, but energy metabolism seems to stay healthy enough in the brain in people who do not …

How to Increase or Decrease SHBG? | Masterjohn Q&A Files #302

Short Answer: SHBG is increased by adiponectin (vitamin K2, insulin sensitivity), thyroid hormone, fasting physiology (AMPK, fat oxidation), and estrogen (especially estrone), while it is decreased by insulin resistance, obesity, the fed state and carbohydrate-dominant physiology, androgens, and polyunsaturated fat. This episode was cut from the original Q&A session that you can find here. DISCLAIMER: I have …

Protein and Longevity | Masterjohn Q&A Files #301

Short Answer: While protein restriction may have value in people with established cancer or kidney disease, cycling robustly between fasting and feeding states is likely to provide all the value that restriction of protein or calories might otherwise provide, and a high protein intake supports bone mass, muscle mass, and the detoxification of carcinogens, all …

Why do my urinary B6 markers say I’m deficient if I’m supplementing and my plasma levels are high-normal? | Masterjohn Q&A Files #300

Short answer: Low or low-normal alkaline phosphatase may raise the plasma B6 level over the cellular level. Tryptophan metabolites in urine reflect the B6 requirement for the kynurenine pathway, and this requirement increases with more estrogen, more inflammation, or a higher protein intake. This episode was cut from the original Q&A session that you can find here. …

The 3 Phases of Fasting: And How to Get Kicked Out of Each One | Masterjohn Q&A Files #299

Short answer: 4-6 hours after a meal the small intestine is emptied and the insulin-to-glucagon ratio declines; 25 hours after, hepatic glycogen is emptied; 5 days later the brain is adapted to ketones and gluconeogenesis reaches its minimal level. Moving from one to the other cannot occur with a small piece of signaling like the bite …

Will reishi, turmeric, or curcumin tank my testosterone? Masterjohn Q&A Files #298

Short answer: Probably not. Animal studies showing a difference use huge doses in an unrealistic context. Human studies show they don’t at doses used. Human effect on PSA is vulnerable to regression to the mean and thoroughly unconvincing. This episode was cut from the original Q&A session that you can find here. DISCLAIMER: I have a PhD …