Question: Is this a biotin deficiency? Beta-hydroxyisovaleric acid is well-established to be the most sensitive marker of biotin status. And actually typically it’s done after leucine challenge, which is, no one does that. And so, generally in my experience, the way they have the reference ranges set on that should, on the ones that do …
Question: Milk thistle, sulforaphane, and blood donation for iron overload If it’s an uptrend, you probably want to do something about it. Someone in that situation could try the Nrf2 stimulators, like milk thistle and sulforaphane. But if it is a genuine uptrend in early stage iron overload, that might be a situation that giving …
Question: Why do vitamin E requirements stay elevated for four years when we stop eating PUFA? None of this really proves that long-term vitamin E status is compromised, and that will make the clinical effect of PUFA be net negative after four or five years. But it does show you that the general relationship between …
Question: How long should our fasting windows be? I think someone who eats three meals a day and no snacking is doing a form of intermittent fasting that most people aren’t doing. And I don’t even have a basis for believing whether that is superior, inferior, or the same as one meal a day in …
Question: What is the value of third party genetic reports? There are very, very few genes where we have really good information on how they impact nutritional requirements, but we have many, many, many genes where we have decent information on what they do mechanistically and where we can speculate things that might be helpful. …
Question: What is the value of the oxidized phospholipids test? It’s interesting to measure, but we don’t have real strong data on its correlation to disease risk. And we also don’t really know how much it reflects the oxidation of lipoproteins in the subendothelial space, which is what matters. If you would like to be …